Japanese study suggests that women’s tolerantsystems age muchslowly.
The alivenessexpectancy in the UK is 79 years for workforceand 82 years for women.
In Japan the life expectancy gap is larger, as women live to 85 years of age on average.
Scientists at the Tokyo Medical and Dental University analysed blood samples from 356 men and women agebetween 20 and 90 to assess the link amongstlifespan and immunological changes.
Professor Katsuiku Hirokawa, who led the research, wrote: ‘It is well known that senescenceis associated with a worseningin the normal function of the immune system, leading to increased susceptibility to various diseases and shortened longevity.
‘However, special(prenominal)dysfunctions in the immune administrationdirectly responsible for this clearyet to be identified.’
Hirokawa and his team piecethat the number of T-cells and B-cells, some(prenominal)of which assistantto protect the body from infection, decreases with age significantly more quickly in men than in women.
Men as well asshowed an age-related decline in red blood cell levels and two types of cytokines that tactical maneuveran important role in keeping the immune system under control.
Additionally, although two cells that attack invaders, CD4 T-cells and natural killer cells, enlargein number as both men and women age, the castof increase is higher in women.
The Japanese scientists published these findings in the journal ‘Immunity & Ageing’ on 15 May.
‘Our findings indicate that the slower charge per unitof decline in these immunological parameters in women than that in men is consistent with the fact that women live longer than do men,’ they said.
The scientists hazardthat the rate of decline is slower in women because female energisehormones help protect the body and the immune system.
Hirokawa said: “The process of senescentis divergentfor men and women for many reasons.
“Women have more estrogenthan men which seems to protect them from cardiovascular disease until menopause. Sex hormones also affect the immune system, especially certain types of lymphocytes.”
In particular, oestrogen has been found to reduce inflammation and boost antibody numbers.
Hirokawa and his colleagues believe that their work could help scientists to determine people’s biological age.
“Because people age at different rates, a person’s immunological parameters could be used to provide an traitof their true biological age,” he said.
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Materials taken from Womens Views on News
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